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KMID : 0379520040200010037
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한국독성학회지
2004 Volume.20 No. 1 p.37 ~ p.42
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Comparative Antitumor Activity of Water Extracts from Fruiting Body of Phellinus linteus, Phellinus baumii and Phellinus gilvus
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Bae Jae-Sung
Hwang Mi-Hyun
Jang Kwang-Ho
Rhee Man-Hee
Lee Keun-Woo
Jo Woo-Sik
Choi Sung-Kuk
Yun Hyo-In
Lim Jong-Hwan
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Abstract
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This study was undertaken to investigate comparative anti-tumor activity of water extracts of Phellinus gilvus (PGE), Phellinus linteus (PLE), and Phellinus baumii (PBE) in vitro. The anti-tumor activity in the present study was evaluated by sulforhodamine B (SRB) and microtetrazolium (MTT) assay in terms of cell survival level. The tumor cells (sarcoma 180 and P388) were treated with PGE, PLE, and PBE (7.5, 15, and 30 mutextrm{g}/ml) and Doxorubicin (DOX) (0.001~10 mutextrm{M}). The results showed that DOX, PGE, and PLE inhibited proliferation showing a dose-dependent manner against both tumor cells. However, PBE was inhibited by the only 30 mutextrm{g}/ml in both cells proliferation. In conclusion, all of PGE, PLE, and PBE used in this study have shown anti-tumor activity against both sarcoma 180 and P388. Among them, PLE was the most effective in anti-tumor activity against sarcoma 180 (p<0.05) and PGE was against P388 in SRB assay. PLE, however, was against P388 (p<0.05) in MTT assay.
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KEYWORD
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Anti-tumor activity, Phellinus spp, Doxorubicin, Sarcoma 180, P388 cell
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